Presymptomatic Dutch-Type Hereditary Cerebral Amyloid Angiopathy-Related Blood Metabolite Alterations

Background: Cerebral amyloid angiopathy (CAA) is one of the major causes intracerebral hemorrhage and vascular dementia in older adults. Early diagnosis will provide clinicians with an opportunity to intervene early suitable strategies, highlighting importance pre-symptomatic CAA biomarkers. Objective: Investigation related blood metabolite alterations Dutch-type hereditary mutation carriers (D-CAA MCs). Methods: Plasma metabolites were measured using mass-spectrometry (AbsoluteIDQ® p400 HR kit) compared between D-CAA MCs (n = 9) non-carriers NCs, n 8) from same pedigree. Metabolites that survived correction for multiple comparisons further additional control groups (cognitively unimpaired adults). Results: 275 plasma, 22 which observed be significantly lower theD-CAAMCs following adjustment potential confounding factors age, sex, APOE ?4 (p < 0.05). After adjusting comparisons, only spermidine remained theD-CAAMCscompared theD-CAA NCs 0.00018). was also cognitively young adult 0.01). Spermidinewas correlate CSF A?40 (rs 0.621, p 0.024), A?42 0.714, 0.006), brain A? load –0.527, 0.030). Conclusion: The current study provides pilot data on linked signals, associated neuropathology are involved several biological pathways have previously been neurodegeneration dementia.